This is the leading pharmacology reference since 1941. Throughout its 60 year history, "Goodman and Gilman's" careful balance of basic science and clinical application has guided practitioners to a clear understanding of the drugs most useful in preventing, diagnosing and treating disease. It details how and why drugs affect different body systems, the chemical properties of drugs, dosage information, drug interactions and toxic effects. Well organised, extensively indexed, rigorously peer reviewed and referenced to the most up-to-date literature in the field, "Goodman and Gilman's" is the definitive resource on therapeutics. It provides coverage of the general principles of pharmacology, including pharmacokinetics and pharmacodynamics, the principles of therapeutics, and the principles of toxicology and gene based therapy.
SECTION I: GENERAL PRINCIPLESIntroduction.Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination.Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect. Principles of Therapeutics.Principles of Toxicology and Treatment of Poisoning.Gene-Based Therapy. SECTION II: DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITESNeurotransmission: The Autonomic and Somatic Motor Nervous Systems.Muscarinic Receptor Agonists and Antagonists.Anticholinesterase Agents. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia.Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists.5-Hydroxytryptamine (Serotonin) Receptor Agonists and Antagonists. SECTION III: DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEMNeurotransmission and the Central Nervous System.History and Principles of Anesthesiology.General Anesthetics.Local Anesthetics.Therapeutic Gases.Hypnotics and Sedatives.Ethanol.Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety.Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania.Drugs Effective in the Therapy of the Epilepsies.Treatment of Central Nervous System Degenerative Disorders.Opioid Analgesics and Antagonists.Drug Addiction and Drug Abuse. SECTION IV: AUTACOIDS
DRUG THERAPY OF INFLAMMATIONIntroduction.Histamine, Bradykinin, and Their Antagonists.Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor.Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout.Drugs Used in the Treatment of Asthma. SECTION V: DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTIONDiuretics.Vasopressin and Other Agents Affecting the Renal Conservation of Water.Renin and Angiotensin.Drugs Used for the Treatment of Myocardial Ischemia.Antihypertensive Agents and the Drug Therapy of Hypertension.Pharmacological Treatment of Heart Failure.Antiarrhythmic Drugs.Drugs Used in the Treatment of Hyperlipoproteinemias. SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTIONA. Treatment of Acid-Peptic Diseases.B. Prokinetic and Anti-Emetic Drugs.C. Gastrointestinal Motility & Luminal Flux. SECTION VII: CHEMOTHERAPY OF PARASITIC INFECTIONSIntroduction.Drugs Used in the Chemotherapy of Protozoal Infections: Malaria.Drugs Used in the Chemotherapy of Protozoal Infections: Trypanosomiasis, Leishmaniasis, Amebiasis, Giardiasis, Trichomoniasis, and Other Protozoal Infections.Drugs Used in the Chemotherapy of Helminthiasis. SECTION VIII: CHEMOTHERAPY OF MICROBIAL DISEASESAntimicrobial Agents: General Considerations.Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections.Antimicrobial Agents: Penicillins, Cephalosporins, and Other B-Lactam Antibiotics.Antimicrobial Agents: The Aminoglycosides.Antimicrobial Agents: Tetracyclines, Chloramphenicol, Erythromycin, and Miscellaneous Antibacterial Agents.Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis and Leprosy.Antimicrobial Agents: Antifungal Agents.Antimicrobial Agents: Antiviral Agents.Antimicrobial Agents: Antiretroviral Agents. SECTION IX: CHEMOTHERAPY OF NEOPLASTIC DISEASESIntroduction.Antineoplastic Agents. SECTION X: DRUGS USED FOR IMMUNOMODULATIONImmunomodulators: Immunosuppressive Agents and Immunostimulants. SECTION XI: DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANSHematopoietic Agents: Growth Factors, Minerals, and Vitamins.Anticoagulant, Thrombolytic, and Antiplatelet Drugs. SECTION XII: HORMONES AND HORMONE ANTAGONISTSAdenohypophyseal Hormones and Their Hypothalamic Releasing Factors.Thyroid and Antithyroid Drugs.Estrogens and Progestins.Androgens.Adrenocorticotropic Hormone
Adrenocortical Steroids and Their Synthetic Analogs
Inhibitors of the Synthesis and Actions of Adrenocortical Hormones.Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas.Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds. SECTION XIII: THE VITAMINSIntroduction.Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid.Fat-Soluble Vitamins: Vitamins A, K, and E. SECTION XIV: DERMATOLOGYDermatological Pharmacology. SECTION XV: OPHTHALMOLOGYOcular Pharmacology. SECTION XVI: TOXICOLOGYHeavy Metals and Heavy-Metal Antagonists.Nonmetallic Environmental Toxicants: Air Pollutants, Solvents, Vapors, and Pesticides. APPENDICESPrinciples of Prescription Order Writing and Patient Compliance Instructions.Design and Optimization of Dosage Regimens